IMMUNE CHECKPOINT INHIBITORS PLUS DEBULKING SURGERY FOR PATIENTS WITH METASTATIC RENAL CELL CARCINOMA: CLINICAL OUTCOMES AND IMMUNOLOGICAL CORRELATES OF A PROSPECTIVE PILOT TRIAL

Abstract Surgical removal of primary tumors reverses tumor-mediated immune suppression in pre-clinical models with metastatic disease.However, how cytoreductive surgery in the metastatic setting modulates the immune responses in patients, Americano Cup especially in the context of immune checkpoint therapy (ICT), is not understood.We report the fir

Purposes In ladle metallurgy, block or whole bag alloy materials and lime are usually added.In recent years, some companies have reported a new process of adding scrap steel to ladle refining furnace.Studying the melting and homogenization mechanism of the above solid substances in the ladle refining process can optimize the refining process and ac

Bidirectional Associative Memories (BAMs) are Artificial Neural Networks frequently utilized in cognitive modeling.While bipolar encoding is commonly used in BAMs for optimal Cases performance, binary encoding presents interesting properties.As such, this study introduces a novel transmission function for binary encoding and compares its performanc

Competitive cognition dynamics are widespread in modern society, especially with the rise of information-technology ecosystem.While previous works mainly focus on internal interactions among individuals, the impacts of the external public opinion environment remain unknown.Here, we propose a heuristic model Egg Turners based on co-evolutionary game

Cereal, oilseed, and protein (COP) production is an important sector contributing to Sustainable Development Goals (SDGs) in Tunisia.COP farms often diversify their production patterns to stabilize their income sources and spread production risk across crops.However, crop diversity may entail an inefficient use and management of resources to achiev